Acetyl hexapeptide-8
Acetyl hexapeptide-8, also called Argireline, is a synthetic cosmetic peptide studied for the appearance of facial lines. Older publications may call the same ingredient acetyl hexapeptide-3.
At a glance
- Regulatory status
- Cosmetic ingredient; cosmetic marketing or an ingredient listing is not FDA drug approval. Claims and intended use determine regulatory treatment.
- Research context
- Acetyl hexapeptide-8, also called Argireline, is a synthetic cosmetic peptide studied for the appearance of facial lines. Older publications may call the same ingredient acetyl hexapeptide-3.
What this is
- Acetyl hexapeptide-8, also called Argireline, is a synthetic cosmetic peptide studied for the appearance of facial lines. Older publications may call the same ingredient acetyl hexapeptide-3.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Acetyl hexapeptide-8, also called Argireline, is a synthetic cosmetic peptide studied for the appearance of facial lines. Older publications may call the same ingredient acetyl hexapeptide-3.
The proposed mechanism concerns neurotransmitter release, but a topical formulation must first reach its biological target. A plausible cellular mechanism does not establish a muscle-relaxing effect through intact human skin. The CIR final assessment clarifies the ingredient's naming and evaluates cosmetic exposure.
Evidence limits
How to read the evidence
The evidence concerns selected topical products and appearance measures. Confirm the actual ingredient name and finished formulation when comparing products. A trial's statistical finding does not tell every reader how noticeable or durable the change would be, and the small study does not settle long-term safety or rare reactions.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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