Acetyl tetrapeptide-5
Acetyl tetrapeptide-5 is a cosmetic ingredient commonly associated with eye-area products. Laboratory activity is not the same as demonstrated reduction of under-eye puffiness in people.
At a glance
- Regulatory status
- Cosmetic ingredient; cosmetic marketing or an ingredient listing is not FDA drug approval. Claims and intended use determine regulatory treatment.
- Research context
- Acetyl tetrapeptide-5 is a cosmetic ingredient commonly associated with eye-area products. Laboratory activity is not the same as demonstrated reduction of under-eye puffiness in people.
What this is
- Acetyl tetrapeptide-5 is a cosmetic ingredient commonly associated with eye-area products. Laboratory activity is not the same as demonstrated reduction of under-eye puffiness in people.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Acetyl tetrapeptide-5 is a cosmetic ingredient commonly associated with eye-area products. Laboratory activity is not the same as demonstrated reduction of under-eye puffiness in people.
A laboratory study assessed its activity in an angiotensin-converting-enzyme assay and then evaluated peptide combinations in cultured human skin fibroblasts. This connects the ingredient to a testable biochemical hypothesis, but an enzyme assay does not demonstrate a clinically meaningful effect on fluid accumulation around the eye. Primary research.
Evidence limits
How to read the evidence
Eye-area appearance has multiple causes, so a broad claim about puffiness needs a clearly defined population and outcome. The useful distinction in this record is between a biochemical signal, a combination's cellular effect and a visible benefit in people. Only the first two were established by the study reviewed here.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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