Angiotensin II
Angiotensin II is a human peptide hormone and a prescription vasoconstrictor used to raise blood pressure in distributive shock.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- GIAPREZA is FDA-approved to increase blood pressure in adults with septic or other distributive shock.
- Research context
- Angiotensin II is a human peptide hormone and a prescription vasoconstrictor used to raise blood pressure in distributive shock.
What this is
- Angiotensin II is a human peptide hormone and a prescription vasoconstrictor used to raise blood pressure in distributive shock.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Angiotensin II is a human peptide hormone and a prescription vasoconstrictor used to raise blood pressure in distributive shock.
Angiotensin II activates vascular angiotensin receptors, tightening blood vessels and increasing systemic vascular resistance. This is useful in a narrowly defined intensive-care setting where circulation is dangerously dilated. Its physiological link to the renin–angiotensin system should not be interpreted as a cardiovascular wellness effect or a treatment for ordinary fatigue. GIAPREZA label.
Evidence limits
How to read the evidence
Improved blood pressure is a surrogate outcome, not proof of restored organ function or survival. Participants were already receiving other vasopressors, so this study does not establish a stand-alone first treatment for every form of shock. Exploratory biomarker or kidney subgroups should not replace the overall randomized mortality result or be presented as confirmed patient-selection rules. Trial population and outcomes.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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