Apraglutide
Apraglutide is an investigational long-acting GLP-2 analogue for short bowel syndrome with intestinal failure, where patients need parenteral fluid or nutrition support.
At a glance
- Evidence stage
- Early human
- Regulatory status
- Investigational; the sponsor reported initiation of the confirmatory STARS-2 phase 3 trial in June 2026.
- Research context
- Apraglutide is an investigational long-acting GLP-2 analogue for short bowel syndrome with intestinal failure, where patients need parenteral fluid or nutrition support.
What this is
- Apraglutide is an investigational long-acting GLP-2 analogue for short bowel syndrome with intestinal failure, where patients need parenteral fluid or nutrition support.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Apraglutide is an investigational long-acting GLP-2 analogue for short bowel syndrome with intestinal failure, where patients need parenteral fluid or nutrition support.
GLP-2 signaling supports intestinal adaptation and absorption. Apraglutide's intended benefit is reducing dependence on parenteral support after loss of functional bowel. It is not a GLP-1 appetite treatment, and the STARS trial does not support generic gut-healing or weight-loss claims in people with an intact intestine.
Evidence limits
How to read the evidence
The sponsor's July 2026 update documents confirmatory development rather than approval. Anatomy, baseline support requirements, and protocol-directed fluid assessment affect interpretation. The study's positive primary endpoint should be presented together with its nonsignificant subgroup outcomes; neither a trial registration nor an extension proves durable independence or long-term safety.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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