Cetrorelix
Cetrorelix is a gonadotropin-releasing hormone antagonist used to prevent a premature luteinizing-hormone surge during controlled ovarian stimulation.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- CETROTIDE is FDA-approved to inhibit premature LH surges in women undergoing controlled ovarian stimulation.
- Research context
- Cetrorelix is a gonadotropin-releasing hormone antagonist used to prevent a premature luteinizing-hormone surge during controlled ovarian stimulation.
What this is
- Cetrorelix is a gonadotropin-releasing hormone antagonist used to prevent a premature luteinizing-hormone surge during controlled ovarian stimulation.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Cetrorelix is a gonadotropin-releasing hormone antagonist used to prevent a premature luteinizing-hormone surge during controlled ovarian stimulation.
Cetrorelix competitively blocks pituitary GnRH receptors, rapidly reducing the LH signal that can trigger ovulation too early during fertility treatment. Unlike a GnRH agonist, it does not require an initial stimulatory phase before suppression. Its role is coordination of ovarian stimulation, rather than directly increasing the ovarian reserve or correcting every cause of infertility. CETROTIDE label.
Evidence limits
How to read the evidence
This trial evaluated a complete assisted-reproduction protocol in selected patients. Similar pregnancy rates do not establish equivalent cumulative live births across repeated cycles or benefit in all infertility diagnoses. Avoiding an LH surge is a useful intermediate outcome, but the distinction between hormonal control, embryo development, pregnancy, and birth remains essential. Trial outcomes; approved purpose.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
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