Daptomycin
Daptomycin is a lipopeptide antibiotic for specified serious Gram-positive infections, including selected Staphylococcus aureus bloodstream infections. It is not a pneumonia treatment.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- US-approved daptomycin treats specified skin and S. aureus bloodstream infections, including adult right-sided endocarditis; age and indication restrictions apply.
- Research context
- Daptomycin is a lipopeptide antibiotic for specified serious Gram-positive infections, including selected Staphylococcus aureus bloodstream infections. It is not a pneumonia treatment.
What this is
- Daptomycin is a lipopeptide antibiotic for specified serious Gram-positive infections, including selected Staphylococcus aureus bloodstream infections. It is not a pneumonia treatment.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Daptomycin is a lipopeptide antibiotic for specified serious Gram-positive infections, including selected Staphylococcus aureus bloodstream infections. It is not a pneumonia treatment.
Daptomycin acts at the bacterial membrane, disrupting processes needed for bacterial survival. That activity is directed against susceptible bacteria rather than a human recovery pathway. The label distinguishes complicated skin infections from bloodstream infection and explicitly excludes pneumonia and left-sided S. aureus endocarditis from its indicated uses. Product label.
Evidence limits
How to read the evidence
Persistent or recurrent bloodstream infection requires assessment for resistant organisms and an unresolved source, such as an infected device. A favorable bloodstream trial does not override the pneumonia limitation. Study participants, infection sites, renal function, and comparator treatment all affect how its results should be interpreted. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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