Desirudin
Desirudin is a recombinant hirudin-related anticoagulant that directly inhibits thrombin. IPRIVASK is a historical US surgical thrombosis-prevention product.
At a glance
- Regulatory status
- IPRIVASK was FDA-approved for deep-vein thrombosis prevention after elective hip replacement; the FDA Purple Book now lists its marketing status as discontinued.
- Research context
- Desirudin is a recombinant hirudin-related anticoagulant that directly inhibits thrombin. IPRIVASK is a historical US surgical thrombosis-prevention product.
What this is
- Desirudin is a recombinant hirudin-related anticoagulant that directly inhibits thrombin. IPRIVASK is a historical US surgical thrombosis-prevention product.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Desirudin is a recombinant hirudin-related anticoagulant that directly inhibits thrombin. IPRIVASK is a historical US surgical thrombosis-prevention product.
Desirudin binds thrombin, interrupting fibrin formation and other thrombin-dependent steps in clot growth. Its studied clinical setting was the high risk of venous thrombosis after hip replacement. This differs from bivalirudin's coronary-intervention role even though both belong to the broader family of direct thrombin inhibitors. IPRIVASK FDA label.
Evidence limits
How to read the evidence
The trial predates contemporary surgical and thrombosis-prevention practice, and its evaluable population was smaller than the randomized population. Reduced venographic thrombosis does not establish a survival advantage. The FDA's discontinued marketing designation also means that an old approval and label should not be presented as proof of current US availability. Trial context; FDA product record.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
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