Dulaglutide
Dulaglutide is the GLP-1 receptor agonist in TRULICITY, used for type 2 diabetes and specified cardiovascular-risk reduction in adults with that disease.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- TRULICITY is US-approved for type 2 diabetes from age 10 and for cardiovascular-risk reduction in eligible adults with type 2 diabetes.
- Research context
- Dulaglutide is the GLP-1 receptor agonist in TRULICITY, used for type 2 diabetes and specified cardiovascular-risk reduction in adults with that disease.
What this is
- Dulaglutide is the GLP-1 receptor agonist in TRULICITY, used for type 2 diabetes and specified cardiovascular-risk reduction in adults with that disease.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Dulaglutide is the GLP-1 receptor agonist in TRULICITY, used for type 2 diabetes and specified cardiovascular-risk reduction in adults with that disease.
Dulaglutide increases glucose-dependent insulin release, reduces glucagon secretion, and slows gastric emptying through GLP-1 receptor activation. These mechanisms can improve glycemic control. The cardiovascular indication is supported by outcomes research and should not be inferred merely from changes in glucose or body weight. Its label does not establish a general anti-aging indication. Product label.
Evidence limits
How to read the evidence
REWIND does not establish the same cardiovascular benefit in people without diabetes. Pediatric glycemic approval relies on separate evidence and is not a pediatric cardiovascular indication. Population, baseline risk, competing treatment options, and gastrointestinal tolerability all matter when translating a relative-risk estimate into an individual clinical discussion. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
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