Enfuvirtide
Enfuvirtide is an HIV-1 fusion-inhibiting peptide marketed as FUZEON. Its role is combination antiretroviral treatment in selected treatment-experienced patients.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- FUZEON was US-approved for combination treatment of treatment-experienced HIV-1 infection; the current FDA application record lists the product as discontinued.
- Research context
- Enfuvirtide is an HIV-1 fusion-inhibiting peptide marketed as FUZEON. Its role is combination antiretroviral treatment in selected treatment-experienced patients.
What this is
- Enfuvirtide is an HIV-1 fusion-inhibiting peptide marketed as FUZEON. Its role is combination antiretroviral treatment in selected treatment-experienced patients.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Enfuvirtide is an HIV-1 fusion-inhibiting peptide marketed as FUZEON. Its role is combination antiretroviral treatment in selected treatment-experienced patients.
Enfuvirtide targets the viral gp41 protein involved in fusion of HIV-1 with a host cell. By interfering with that step, it blocks viral entry rather than suppressing an intracellular replication enzyme. It is used with other active antiretrovirals; a fusion inhibitor alone is not a complete treatment strategy or a cure for HIV. Product label.
Evidence limits
How to read the evidence
The result supports an add-on strategy in a historical resistant-virus population, not superiority over all modern combinations. FDA currently lists FUZEON as discontinued. FDA application record. The accessible label is dated 2018; this does not establish a currently available product or justify an unregulated replacement. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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