Eptifibatide
Eptifibatide is a cyclic peptide antiplatelet drug that blocks the platelet glycoprotein IIb/IIIa receptor.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- US eptifibatide products are approved in specified acute coronary syndrome and percutaneous coronary intervention settings.
- Research context
- Eptifibatide is a cyclic peptide antiplatelet drug that blocks the platelet glycoprotein IIb/IIIa receptor.
What this is
- Eptifibatide is a cyclic peptide antiplatelet drug that blocks the platelet glycoprotein IIb/IIIa receptor.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Eptifibatide is a cyclic peptide antiplatelet drug that blocks the platelet glycoprotein IIb/IIIa receptor.
Activated platelets use glycoprotein IIb/IIIa to bind fibrinogen and form bridges between cells. Eptifibatide interrupts that final aggregation step. This is a different target from thrombin inhibition or prevention of clotting-factor production. Its coronary indication concerns a monitored balance between preventing ischemic events and causing bleeding. Prescribing information.
Evidence limits
How to read the evidence
PURSUIT was conducted before many current coronary intervention and oral antiplatelet practices. Its result should therefore be interpreted within the trial's accompanying treatment and risk profile. A drug that reduces platelet aggregation does not treat every cause of chest pain, and its procedural or acute-care evidence does not establish a role in general cardiovascular wellness. Original study context; approved clinical settings.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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