Histrelin
Histrelin is a potent GnRH agonist. The SUPPRELIN LA implant suppresses the prematurely activated reproductive hormone axis in central precocious puberty.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- SUPPRELIN LA is FDA-approved for children with central precocious puberty; evidence and approval should be tied to that product and diagnosis.
- Research context
- Histrelin is a potent GnRH agonist. The SUPPRELIN LA implant suppresses the prematurely activated reproductive hormone axis in central precocious puberty.
What this is
- Histrelin is a potent GnRH agonist. The SUPPRELIN LA implant suppresses the prematurely activated reproductive hormone axis in central precocious puberty.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Histrelin is a potent GnRH agonist. The SUPPRELIN LA implant suppresses the prematurely activated reproductive hormone axis in central precocious puberty.
After an initial stimulatory phase, sustained GnRH-receptor activation reduces pituitary responsiveness and lowers LH, FSH, and sex steroids. In central precocious puberty, this interrupts an unusually early activation of normal pubertal signaling. It does not treat every cause of early physical development, including conditions driven independently of the central hormone axis. SUPPRELIN LA label.
Evidence limits
How to read the evidence
A one-year hormone-suppression result should not be restated as a measured increase in final adult height. Clinical assessment also considers growth pattern, skeletal maturation, cause of early puberty, and the child's experience. Evidence from this pediatric implant study does not establish every proposed use of puberty suppression or allow other histrelin formulations to inherit the same indication automatically. Study scope; product-specific indication.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
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