Human chorionic gonadotropin
Human chorionic gonadotropin, or hCG, is a glycoprotein hormone with LH-like effects on the ovaries and testes; it is not an established weight-loss treatment.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- PREGNYL is FDA-approved for selected anovulatory infertility, male hypogonadotropic hypogonadism, and nonobstructive prepubertal cryptorchidism. hCG is not approved for weight loss.
- Research context
- Human chorionic gonadotropin, or hCG, is a glycoprotein hormone with LH-like effects on the ovaries and testes; it is not an established weight-loss treatment.
What this is
- Human chorionic gonadotropin, or hCG, is a glycoprotein hormone with LH-like effects on the ovaries and testes; it is not an established weight-loss treatment.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Human chorionic gonadotropin, or hCG, is a glycoprotein hormone with LH-like effects on the ovaries and testes; it is not an established weight-loss treatment.
hCG activates the same receptor as luteinizing hormone, supporting gonadal steroid production and, in a prepared ovarian follicle, ovulation. In selected men with deficient pituitary stimulation it can stimulate testicular androgen production. These endocrine actions do not establish fat mobilization or appetite suppression. PREGNYL pharmacology and indications.
Evidence limits
How to read the evidence
Approved endocrine uses should not be confused with internet weight-loss products or universal treatment for low testosterone. An absent ovarian response caused by primary gonadal failure differs from inadequate pituitary stimulation. The FDA also warns that severe calorie restriction used in some hCG diets carries independent risks, so weight change during such a program cannot establish a drug effect. Indication boundaries; FDA warning.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
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