Icatibant
Icatibant is a bradykinin B2-receptor blocker in FIRAZYR. US labeling concerns acute hereditary angioedema attacks in adults.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- FIRAZYR is US-approved for acute hereditary angioedema attacks in adults aged 18 years and older.
- Research context
- Icatibant is a bradykinin B2-receptor blocker in FIRAZYR. US labeling concerns acute hereditary angioedema attacks in adults.
What this is
- Icatibant is a bradykinin B2-receptor blocker in FIRAZYR. US labeling concerns acute hereditary angioedema attacks in adults.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Icatibant is a bradykinin B2-receptor blocker in FIRAZYR. US labeling concerns acute hereditary angioedema attacks in adults.
Icatibant competes with bradykinin at the B2 receptor. In hereditary angioedema, excess bradykinin promotes fluid leakage and swelling; blocking that receptor can reduce attack symptoms. This is different from an antihistamine mechanism, and a shared appearance of swelling does not mean that different angioedema causes respond identically. Product label.
Evidence limits
How to read the evidence
The trial measured acute symptom relief and rescue-treatment use; it did not establish prevention of future attacks or correction of C1-inhibitor dysfunction. The strongest randomized comparison involved skin and abdominal attacks. Adult US labeling and the study population should not be silently extended to children or unrelated forms of angioedema. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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