Lixisenatide
Lixisenatide is a GLP-1 receptor agonist. Its standalone US product ADLYXIN is discontinued, while SOLIQUA combines lixisenatide with insulin glargine for adult type 2 diabetes.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- FDA lists ADLYXIN discontinued. SOLIQUA, containing lixisenatide plus insulin glargine, is US-approved for adult type 2 diabetes; Parkinson treatment remains investigational.
- Research context
- Lixisenatide is a GLP-1 receptor agonist. Its standalone US product ADLYXIN is discontinued, while SOLIQUA combines lixisenatide with insulin glargine for adult type 2 diabetes.
What this is
- Lixisenatide is a GLP-1 receptor agonist. Its standalone US product ADLYXIN is discontinued, while SOLIQUA combines lixisenatide with insulin glargine for adult type 2 diabetes.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Lixisenatide is a GLP-1 receptor agonist. Its standalone US product ADLYXIN is discontinued, while SOLIQUA combines lixisenatide with insulin glargine for adult type 2 diabetes.
Lixisenatide enhances glucose-dependent insulin release, reduces glucagon secretion, and slows gastric emptying. SOLIQUA also contains basal insulin, giving the combination a second mechanism and additional risks. Experimental neurological research concerns lixisenatide itself; it should not be confused with evidence for the insulin-containing combination or with a neurological treatment authorization. Product label.
Evidence limits
How to read the evidence
The FDA discontinued-biologic list documents ADLYXIN status. FDA list. Parkinson trial findings do not establish a disease-modifying effect or an approved indication. Clinical results for a single GLP-1 molecule, a fixed combination, and other members of the GLP-1 class need separate interpretation. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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