Motixafortide
Motixafortide is a cyclic peptide CXCR4 antagonist used to move hematopoietic stem cells from bone marrow into the bloodstream for collection.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- APHEXDA is FDA-approved with filgrastim to mobilize hematopoietic stem cells for collection and subsequent autologous transplantation in adults with multiple myeloma.
- Research context
- Motixafortide is a cyclic peptide CXCR4 antagonist used to move hematopoietic stem cells from bone marrow into the bloodstream for collection.
What this is
- Motixafortide is a cyclic peptide CXCR4 antagonist used to move hematopoietic stem cells from bone marrow into the bloodstream for collection.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Motixafortide is a cyclic peptide CXCR4 antagonist used to move hematopoietic stem cells from bone marrow into the bloodstream for collection.
CXCR4 helps retain stem cells in their bone-marrow environment through signaling with CXCL12. Motixafortide blocks this interaction, increasing circulating cells available for apheresis. The purpose is to obtain a transplant graft; mobilizing cells is not itself evidence of tissue rejuvenation or treatment of the underlying myeloma. APHEXDA prescribing information.
Evidence limits
How to read the evidence
Successful collection can help a transplant proceed, but this trial does not establish improved myeloma survival or prove that mobilized cells repair unrelated organs. The findings concern a specific combination and transplant population. Different collection thresholds and laboratory counting methods can change the reported success rate without representing contradictory trials. GENESIS methods and results; prescribing information.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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