Murepavadin
Murepavadin, formerly POL7080, is a pathogen-selective peptide antibiotic investigated against Pseudomonas aeruginosa. Intravenous and inhaled development must be separated.
At a glance
- Evidence stage
- Early human
- Regulatory status
- Investigational; the intravenous PRISM phase 3 program was stopped after excess acute kidney injury. Inhaled development is a separate program.
- Research context
- Murepavadin, formerly POL7080, is a pathogen-selective peptide antibiotic investigated against Pseudomonas aeruginosa. Intravenous and inhaled development must be separated.
What this is
- Murepavadin, formerly POL7080, is a pathogen-selective peptide antibiotic investigated against Pseudomonas aeruginosa. Intravenous and inhaled development must be separated.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Murepavadin, formerly POL7080, is a pathogen-selective peptide antibiotic investigated against Pseudomonas aeruginosa. Intravenous and inhaled development must be separated.
Murepavadin targets the outer-membrane machinery of Pseudomonas rather than functioning as a general immune stimulant. Its narrow antibacterial scope makes organism identification and formulation central to the research question. The developer's annual report describes the subsequent shift away from intravenous development; a promising antimicrobial mechanism does not negate a clinical safety failure.
Evidence limits
How to read the evidence
The 2021 sponsor prospectus distinguishes closure of the intravenous studies from continued inhaled investigation. These are commercial-source development records, not comparative evidence that inhalation solves the kidney risk. The guide therefore does not present murepavadin as a proven antibiotic option or general antimicrobial peptide supplement.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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