Nangibotide
Nangibotide is an investigational peptide modulator of the TREM-1 inflammatory pathway studied in critical illness, including septic shock.
At a glance
- Evidence stage
- Early human
- Regulatory status
- Investigational critical-care therapy; the ASTONISH phase 2b study did not meet its prespecified primary endpoint.
- Research context
- Nangibotide is an investigational peptide modulator of the TREM-1 inflammatory pathway studied in critical illness, including septic shock.
What this is
- Nangibotide is an investigational peptide modulator of the TREM-1 inflammatory pathway studied in critical illness, including septic shock.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Nangibotide is an investigational peptide modulator of the TREM-1 inflammatory pathway studied in critical illness, including septic shock.
TREM-1 can amplify inflammatory responses in myeloid immune cells. Nangibotide aims to moderate that amplification, while soluble TREM-1 has been investigated as a marker for selecting patients. The ASTONISH publication tests a targeted sepsis hypothesis, not the idea that suppressing inflammation is beneficial for every person or every infection.
Evidence limits
How to read the evidence
The biomarker strategy remains an important research question, but an exploratory cutoff must not be reported as a successful confirmatory endpoint. Sepsis combines infection, organ dysfunction, background therapies, and changing immune states, so mechanistic labels alone cannot predict benefit. The study supports continued investigation of a defined population, while leaving efficacy, patient selection, and durable clinical outcomes unresolved.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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