Nesiritide
Nesiritide is recombinant human B-type natriuretic peptide, historically marketed as NATRECOR for selected acute heart-failure symptoms.
At a glance
- Regulatory status
- NATRECOR's FDA approval was withdrawn June 15, 2020 after marketing ceased. FDA subsequently determined that withdrawal was not for safety or effectiveness reasons.
- Research context
- Nesiritide is recombinant human B-type natriuretic peptide, historically marketed as NATRECOR for selected acute heart-failure symptoms.
What this is
- Nesiritide is recombinant human B-type natriuretic peptide, historically marketed as NATRECOR for selected acute heart-failure symptoms.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Nesiritide is recombinant human B-type natriuretic peptide, historically marketed as NATRECOR for selected acute heart-failure symptoms.
Nesiritide activates natriuretic-peptide receptors and increases cyclic GMP, relaxing blood vessels and lowering cardiac filling pressures. The historical indication concerned acutely decompensated heart failure with dyspnea at rest or minimal activity. A reduction in pressure is a physiological effect, not automatic proof of fewer admissions or longer survival. Historical FDA label.
Evidence limits
How to read the evidence
NATRECOR belongs in a historical clinical reference rather than a list of currently marketed US options. The 2020 Federal Register notice withdrew the application at the applicant's request after discontinuation. A separate 2021 FDA determination found that discontinuation was not for safety or effectiveness reasons; that finding did not restore the withdrawn application or demonstrate commercial availability. Withdrawal notice; subsequent FDA determination.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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