Parathyroid hormone
Parathyroid hormone regulates calcium and phosphate. Full-length PTH(1–84), active fragments, and sustained-release prodrugs are distinct clinical products.
At a glance
- Regulatory status
- NATPARA received FDA approval for hypoparathyroidism-related hypocalcemia, but manufacturing ended in 2024 and US special-use shipments ended December 31, 2025.
- Research context
- Parathyroid hormone regulates calcium and phosphate. Full-length PTH(1–84), active fragments, and sustained-release prodrugs are distinct clinical products.
What this is
- Parathyroid hormone regulates calcium and phosphate. Full-length PTH(1–84), active fragments, and sustained-release prodrugs are distinct clinical products.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Parathyroid hormone regulates calcium and phosphate. Full-length PTH(1–84), active fragments, and sustained-release prodrugs are distinct clinical products.
PTH coordinates mineral balance through actions on kidney and bone and through vitamin D metabolism. NATPARA contained recombinant full-length PTH(1–84), used alongside calcium and vitamin D when conventional treatment was insufficient. This umbrella entry should therefore be read as a hormone and historical-product reference, not as a currently available single medicine. NATPARA FDA label.
Evidence limits
How to read the evidence
Approval and supply must be separated. A December 2025 FDA-hosted manufacturer notice states that the US Special Use Program closed at year end and no further shipments would be sent. An old label or Purple Book record cannot establish present access. Current hypoparathyroidism alternatives require their own product evidence; the historical NATPARA record is not an instruction to obtain remaining stock. Final program closure notice.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
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