Pasireotide
Pasireotide is a somatostatin analogue that suppresses ACTH secretion in Cushing disease. Short-acting SIGNIFOR and long-acting formulations have distinct clinical labeling.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- The cited US-approved SIGNIFOR injection treats adult Cushing disease when pituitary surgery is not an option or has not been curative; other formulations require separate review.
- Research context
- Pasireotide is a somatostatin analogue that suppresses ACTH secretion in Cushing disease. Short-acting SIGNIFOR and long-acting formulations have distinct clinical labeling.
What this is
- Pasireotide is a somatostatin analogue that suppresses ACTH secretion in Cushing disease. Short-acting SIGNIFOR and long-acting formulations have distinct clinical labeling.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Pasireotide is a somatostatin analogue that suppresses ACTH secretion in Cushing disease. Short-acting SIGNIFOR and long-acting formulations have distinct clinical labeling.
Pasireotide binds several somatostatin receptor subtypes. Receptor subtype 5 is often expressed on ACTH-producing pituitary tumor cells, and receptor activation can reduce ACTH and downstream cortisol secretion. This gives a mechanistic rationale for Cushing disease, but receptor binding alone cannot predict complete hormonal control in every patient. Product label.
Evidence limits
How to read the evidence
The short-acting study does not establish identical results for every long-acting presentation, every cause of Cushing syndrome, or acromegaly. Normalization of urinary cortisol is an important marker, but it is not synonymous with tumor eradication or guaranteed reversal of all disease complications. Ongoing interpretation must distinguish hormone control from overall clinical recovery. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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