Pegcetacoplan
Pegcetacoplan is a complement C3 inhibitor. Its systemic EMPAVELI and ocular SYFOVRE products have different indications and safety profiles.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- EMPAVELI covers adult PNH and C3G/primary IC-MPGN from age 12 to reduce proteinuria and kidney-function loss. SYFOVRE covers geographic atrophy secondary to age-related macular degeneration.
- Research context
- Pegcetacoplan is a complement C3 inhibitor. Its systemic EMPAVELI and ocular SYFOVRE products have different indications and safety profiles.
What this is
- Pegcetacoplan is a complement C3 inhibitor. Its systemic EMPAVELI and ocular SYFOVRE products have different indications and safety profiles.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Pegcetacoplan is a complement C3 inhibitor. Its systemic EMPAVELI and ocular SYFOVRE products have different indications and safety profiles.
By binding C3 and its activated fragment, pegcetacoplan interrupts a central step in complement activation. This can reduce complement-mediated injury, but it also weakens an important defense against infection. Systemic treatment for blood or kidney disease and local treatment for retinal disease must be assessed as distinct products. EMPAVELI label; SYFOVRE label.
Evidence limits
How to read the evidence
The current August 2026 EMPAVELI indication includes reducing loss of kidney function as well as proteinuria; an older article or label can omit that expansion. Conversely, the 26-week publication alone cannot establish lifetime avoidance of kidney failure. Kidney, PNH, and retinal findings should remain attached to their own population, formulation, and outcome. Current EMPAVELI indication and studies; VALIANT.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
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