Pemvidutide
Pemvidutide, formerly ALT-801, is an investigational dual GLP-1 and glucagon receptor agonist studied in metabolic disease, obesity, and steatohepatitis.
At a glance
- Evidence stage
- Early human
- Regulatory status
- Investigational metabolic therapy; positive phase 2 liver findings do not constitute approval or establish all intended indications.
- Research context
- Pemvidutide, formerly ALT-801, is an investigational dual GLP-1 and glucagon receptor agonist studied in metabolic disease, obesity, and steatohepatitis.
What this is
- Pemvidutide, formerly ALT-801, is an investigational dual GLP-1 and glucagon receptor agonist studied in metabolic disease, obesity, and steatohepatitis.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Pemvidutide, formerly ALT-801, is an investigational dual GLP-1 and glucagon receptor agonist studied in metabolic disease, obesity, and steatohepatitis.
The GLP-1 component targets appetite and glucose-related signaling, while glucagon receptor activity contributes a distinct hepatic and metabolic action. The balance is specific to pemvidutide and cannot be assumed equivalent to other dual agonists. IMPACT tested this approach in biopsy-confirmed metabolic dysfunction-associated steatohepatitis, or MASH, with moderate-to-advanced fibrosis.
Evidence limits
How to read the evidence
The registered IMPACT protocol and publication identify two separate histological goals. Reporting only MASH resolution would omit a material negative result. A biopsy surrogate over 24 weeks differs from fewer cirrhosis complications, transplantation, or deaths. Results from a selected fibrosis population should also not be presented as proof of benefit for every person with fatty liver or for unsupervised weight management.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
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