Plecanatide
Plecanatide is the guanylate cyclase-C agonist in TRULANCE, a prescription treatment for adult chronic idiopathic constipation and constipation-predominant irritable bowel syndrome.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- TRULANCE is US-approved for CIC and IBS-C in adults. It is contraindicated below age 6, and the label advises avoiding use from age 6 to under 18.
- Research context
- Plecanatide is the guanylate cyclase-C agonist in TRULANCE, a prescription treatment for adult chronic idiopathic constipation and constipation-predominant irritable bowel syndrome.
What this is
- Plecanatide is the guanylate cyclase-C agonist in TRULANCE, a prescription treatment for adult chronic idiopathic constipation and constipation-predominant irritable bowel syndrome.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Plecanatide is the guanylate cyclase-C agonist in TRULANCE, a prescription treatment for adult chronic idiopathic constipation and constipation-predominant irritable bowel syndrome.
Plecanatide resembles the intestinal signaling peptide uroguanylin. It activates receptors on the bowel lining, increasing cyclic GMP and fluid secretion into the intestinal lumen. This can improve stool passage. The mechanism is local bowel signaling, and it should not be conflated with systemic regenerative effects or proof that underlying causes of constipation have resolved. Product label.
Evidence limits
How to read the evidence
The responder difference supports a benefit for some patients but also shows that most did not meet the full durable-response threshold. CIC and IBS-C have separate eligibility and outcome definitions. Comparisons with linaclotide require direct evidence; sharing a receptor does not establish identical benefit, safety, or pediatric authorization. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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