Secretin
Secretin is an intestinal peptide hormone. Synthetic human secretin in ChiRhoStim is used as a diagnostic aid for selected pancreatic, gastrin, and endoscopic assessments.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- ChiRhoStim is US-approved for specified diagnostic stimulation of pancreatic or gastrin secretion and to aid identification of pancreatic anatomy during ERCP.
- Research context
- Secretin is an intestinal peptide hormone. Synthetic human secretin in ChiRhoStim is used as a diagnostic aid for selected pancreatic, gastrin, and endoscopic assessments.
What this is
- Secretin is an intestinal peptide hormone. Synthetic human secretin in ChiRhoStim is used as a diagnostic aid for selected pancreatic, gastrin, and endoscopic assessments.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Secretin is an intestinal peptide hormone. Synthetic human secretin in ChiRhoStim is used as a diagnostic aid for selected pancreatic, gastrin, and endoscopic assessments.
Secretin stimulates pancreatic duct cells to release bicarbonate-rich fluid. This helps neutralize acid during digestion and, in a diagnostic setting, creates a measurable pancreatic response. The product can also stimulate gastrin secretion in a way useful for evaluating suspected gastrinoma. A diagnostic response is not evidence that secretin repairs pancreatic tissue. Product label.
Evidence limits
How to read the evidence
A positive or reduced response must be interpreted with the actual test method and other diagnostic findings. Historical comparisons of secretin preparations do not establish benefit for autism, nonspecific digestive symptoms, or chronic pancreatitis treatment. The clinical question is what the stimulated secretion reveals, not whether a naturally occurring peptide is generally beneficial. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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