Sincalide
Sincalide is a synthetic cholecystokinin analogue used as a diagnostic aid. Its effects on gallbladder contraction and pancreatic secretion help clinicians measure digestive function.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- US-approved sincalide labeling covers specified adult diagnostic uses involving gallbladder contraction, pancreatic secretion with secretin, and intestinal imaging.
- Research context
- Sincalide is a synthetic cholecystokinin analogue used as a diagnostic aid. Its effects on gallbladder contraction and pancreatic secretion help clinicians measure digestive function.
What this is
- Sincalide is a synthetic cholecystokinin analogue used as a diagnostic aid. Its effects on gallbladder contraction and pancreatic secretion help clinicians measure digestive function.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Sincalide is a synthetic cholecystokinin analogue used as a diagnostic aid. Its effects on gallbladder contraction and pancreatic secretion help clinicians measure digestive function.
Sincalide stimulates gallbladder contraction and bile release, reproducing part of the physiological response to cholecystokinin. It also affects pancreatic secretion and gastrointestinal motility. In diagnostic testing, the measurable response is useful information about function; the drug is not prescribed on that basis to regenerate the gallbladder or permanently correct a motility disorder. Product label.
Evidence limits
How to read the evidence
A result depends on the clinical question, fasting state, concurrent medicines, and local measurement technique. A healthy-volunteer reference study cannot establish diagnostic accuracy in every patient population. Sincalide-related pain during a test is not by itself a diagnosis, and its diagnostic role should remain distinct from treatment claims. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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