Teduglutide
Teduglutide is the GLP-2 analogue in GATTEX, used in short bowel syndrome when patients depend on intravenous nutrition or fluids.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- GATTEX is US-approved for adults and children aged 1 year and older with short bowel syndrome who depend on parenteral support.
- Research context
- Teduglutide is the GLP-2 analogue in GATTEX, used in short bowel syndrome when patients depend on intravenous nutrition or fluids.
What this is
- Teduglutide is the GLP-2 analogue in GATTEX, used in short bowel syndrome when patients depend on intravenous nutrition or fluids.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Teduglutide is the GLP-2 analogue in GATTEX, used in short bowel syndrome when patients depend on intravenous nutrition or fluids.
Teduglutide activates GLP-2 receptors involved in intestinal adaptation, promoting pathways that support the absorptive lining and fluid uptake. This aims to help the remaining bowel absorb more in short bowel syndrome. It is a different receptor system and clinical purpose from GLP-1 medicines used in diabetes; the similar names should not obscure that distinction. Product label.
Evidence limits
How to read the evidence
Trial participants had established intestinal failure and structured assessment of fluid and nutritional requirements. This evidence does not support use for nonspecific bloating, ordinary gastrointestinal discomfort, or general intestinal wellness. Responses differ with remaining anatomy and clinical circumstances, and reduction of support must be distinguished from permanent recovery after treatment stops. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
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