Terlipressin
Terlipressin is a vasopressin analogue in TERLIVAZ, used to improve kidney function in adults with rapidly worsening hepatorenal syndrome.
At a glance
- Evidence stage
- Approved use
- Regulatory status
- TERLIVAZ is US-approved for adults with hepatorenal syndrome and rapid kidney-function decline. It carries a boxed warning for serious or fatal respiratory failure.
- Research context
- Terlipressin is a vasopressin analogue in TERLIVAZ, used to improve kidney function in adults with rapidly worsening hepatorenal syndrome.
What this is
- Terlipressin is a vasopressin analogue in TERLIVAZ, used to improve kidney function in adults with rapidly worsening hepatorenal syndrome.
What this isn't
- A recommendation to use, prepare, combine, or administer a product
- Evidence that a related molecule or a differently formulated product has the same effects
Key terms
Terlipressin is a vasopressin analogue in TERLIVAZ, used to improve kidney function in adults with rapidly worsening hepatorenal syndrome.
Terlipressin constricts blood vessels through vasopressin-receptor activity, particularly in the splanchnic circulation. In hepatorenal syndrome, the intended effect is to improve effective arterial circulation and renal blood flow. It is not a direct kidney-regeneration therapy and does not treat every cause of acute kidney injury in a patient with liver disease. Product label.
Evidence limits
How to read the evidence
The label states that patients with very high baseline creatinine are unlikely to benefit. CONFIRM excluded several conditions, including uncontrolled infection and shock, which limits generalization. Patient selection requires distinguishing hepatorenal physiology from other kidney injuries and balancing renal response against respiratory and ischemic risk. Product-specific scope.
Sources appraised 2026-10-28. Educational information; not medical advice. Study findings apply to the populations, preparations and outcomes described.
External sources and citations
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